Understanding G protein-coupled receptors and their role in the CNS
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Understanding G protein-coupled receptors and their role in the CNS

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Published by Oxford University Press in Oxford, New York .
Written in English


  • G proteins -- Receptors.,
  • Cell receptors.

Book details:

Edition Notes

Statementedited by Menelas N. Pangalos and Ceri H. Davies.
SeriesMolecular and cellular neurobiology
ContributionsPangalos, Menelas N., Davies, Ceri H.
The Physical Object
Paginationxix, 628 p. :
Number of Pages628
ID Numbers
Open LibraryOL18181317M
ISBN 100198509162

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ISBN: OCLC Number: Description: xix, pages: illustrations ; 24 cm. Series Title: Molecular and cellular neurobiology :// G Protein-coupled Receptors: Molecular Pharmacology provides a clear summary of the current knowledge in this fast-evolving field. The book sets out with an introduction to signalling molecules and their receptors, and an overview of the technical approaches used to investigate these :// Kumaran Kolandaivelu, Deepak L. Bhatt, in Platelets (Fourth Edition), G Protein Coupled Receptors (GPCRs) GPCRs couple platelets to their external chemical environment and facilitate communication via a range of signaling molecules (see Chapter 18). 30,41,42 Their critical role in transducing between extracellular and intracellular environments makes them a prime pharmaceutical   G-protein coupled receptors, the largest group of seven transmembrane receptors, are involved in neuronal signal transduction in response to various signals such as hormones and neurotransmitters. In Alzheimer’s disease, GPCRs are involved in phosphorylation of Tau through various downstream kinases such as GSK-3β, CDK-5 and ERKs signalling

G protein-coupled GABAergic receptors and mood disorders. There is some evidence that G protein-coupled GABA-B receptors play a role in mood disorders. Baclofen, a GABA-B receptor agonist, has been shown in a small number of patients to induce a reversible depression that remits following discontinuation of the :// G-protein-coupled receptors (GPCRs) constitute the largest family of membrane receptors in humans, and ~34% of marketed drugs target this family. Since their discovery, this receptor family has been both pharmacologically and biologically important in the treatment of different pathological ://   G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors (GPLR), is a large group of evolutionary related proteins that are cell surface receptor that detect molecules outside the cell and activate cellular responses. Coupling with G proteins, they are called G protein-coupled receptors (GPCRs) are the largest class of membrane proteins in the human genome. The term "7TM receptor" is commonly used interchangeably with "GPCR", although there are some receptors with seven transmembrane domains that do not signal through G ://?familyId=

  G-protein coupled receptors: This is the largest class of receptors. These receptors are of 3 types as family-A, Family-B, Family-C. These receptors act through both ligand-gated channel and also enzyme-linked pathways. The response through these receptors takes in few seconds. Ex: Muscarinic acetylcholine receptors. Kinase linked or enzymatic   The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors. ChemBioChem 8, 19–24 (). CAS Article Google Scholar G protein–coupled receptors (GPCRs) continue to be important discovery targets for the treatment of type 2 diabetes mellitus (T2DM). Many GPCRs are directly involved in the development of insulin resistance and β -cell dysfunction, and in the etiology of inflammation that can lead to obesity-induced T2DM. This review summarizes the current literature describing a number of well-validated The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid (CB) receptor, whose role in the gastrointestinal (GI) tract remains unknown. Here we studied the significance of GPR55 in the regulation of GI 55 mRNA and protein expression